Gene Expression Commons

 

Each gene has a different dynamic-range of its expression

Gene Expression Commons provides dynamic-range of each gene by meta analysis of thousands of microarray data. By mapping your data onto it, you can profile absolute expression of any gene on the microarray.

Goodbye, profiling relative difference of gene expression in pari-wise comparison.

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641 cell types

Many cell types including Weissman Lab mouse hematopoiesis series and ImmGen series are publicly available. Recent additions are...

Barres young adult astrocytes d1 post 1h transient ischemia with reperfusion	2 months ago
Barres young adult astrocytes d7 post 1h transient ischemia with reperfusion	2 months ago
Barres young adult quiescent astrocytes d1 post sham stroke	2 months ago
Activated SVZ NSCs (GFAP+/CD133+/EGFR+) - (1 of 3 omitted)	2 months ago
Quiescent SVZ NSCs (GFAP+/CD133+/EGFR-)	2 months ago
Barres young adult quiescent astrocytes d1 post 5mg/kg injection	2 months ago

45 models

A model represents biological relationship of cell types. Recent additions to publicly available models are...

Mouse CNS, neurogenesis, development, inflammation and glioma	97 cell types
HSC and Progenitors	14 cell types
Human NSAID Paper	11 cell types
Mouse NSAID Paper	8 cell types
Vessel forming mesenchymal stromal cell populations public	6 cell types
Simplified Mouse Hematopoiesis	13 cell types

Open Platform

You can submit your private cell type by upload your microarray data, design your model, and share private data with your collaborators. Please open the data to public when your project will be published.

Accelerate Discovery with Confidence

Gene Expression Commons has been used/cited in publications such as...

• Distinct skeletal stem cell types orchestrate long bone skeletogenesis.
  Ambrosi TH, Sinha R, Steininger HM, Hoover MY, Murphy MP, Koepke LS, Wang Y, Lu WJ, Morri M, Neff NF, Weissman IL, Longaker MT, Chan CK.
  Elife. 2021 Jul 19;10. pii: e66063. doi: 10.7554/eLife.66063
  PMID: 34280086
• Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias.
  Raundhal M, Ghosh S, Myers SA, Cuoco MS, Singer M, Carr SA, Waikar SS, Bonventre JV, Ritz J, Stone RM, Steensma DP, Regev A, Glimcher LH.
  Nat Immunol. 2021 Apr;22(4):520-529. doi: 10.1038/s41590-021-00895-4
  PMID: 33753942
• Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells.
  Zaro BW, Noh JJ, Mascetti VL, Demeter J, George B, Zukowska M, Gulati GS, Sinha R, Flynn RA, Banuelos A, Zhang A, Wilkinson AC, Jackson P, Weissman IL.
  Elife. 2020 Nov 25;9. pii: e62210. doi: 10.7554/eLife.62210
  PMID: 33236985
• Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis.
  Rodriguez-Fraticelli AE, Weinreb C, Wang SW, Migueles RP, Jankovic M, Usart M, Klein AM, Lowell S, Camargo FD.
  Nature. 2020 Jul;583(7817):585-589. doi: 10.1038/s41586-020-2503-6
  PMID: 32669716
• Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro.
  Luchsinger LL, Strikoudis A, Danzl NM, Bush EC, Finlayson MO, Satwani P, Sykes M, Yazawa M, Snoeck HW.
  Cell Stem Cell. 2019 Aug 1;25(2):225-240.e7. doi: 10.1016/j.stem.2019.05.002
  PMID: 31178255
• Complex mammalian-like haematopoietic system found in a colonial chordate.
  Rosental B, Kowarsky M, Seita J, Corey DM, Ishizuka KJ, Palmeri KJ, Chen SY, Sinha R, Okamoto J, Mantalas G, Manni L, Raveh T, Clarke DN, Tsai JM, Newman AM, Neff NF, Nolan GP, Quake SR, Weissman IL, Voskoboynik A.
  Nature. 2018 Dec;564(7736):425-429. doi: 10.1038/s41586-018-0783-x
  PMID: 30518860
• Identification of the Human Skeletal Stem Cell.
  Chan CKF, Gulati GS, Sinha R, Tompkins JV, Lopez M, Carter AC, Ransom RC, Reinisch A, Wearda T, Murphy M, Brewer RE, Koepke LS, Marecic O, Manjunath A, Seo EY, Leavitt T, Lu WJ, Nguyen A, Conley SD, Salhotra A, Ambrosi TH, Borrelli MR, Siebel T, Chan K, Schallmoser K, Seita J, Sahoo D, Goodnough H, Bishop J, Gardner M, Majeti R, Wan DC, Goodman S, Weissman IL, Chang HY, Longaker MT.
  Cell. 2018 Sep 20;175(1):43-56.e21. doi: 10.1016/j.cell.2018.07.029
  PMID: 30241615
• Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.
  Agathocleous M, Meacham CE, Burgess RJ, Piskounova E, Zhao Z, Crane GM, Cowin BL, Bruner E, Murphy MM, Chen W, Spangrude GJ, Hu Z, DeBerardinis RJ, Morrison SJ.
  Nature. 2017 Sep 28;549(7673):476-481. doi: 10.1038/nature23876
  PMID: 28825709
• p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress.
  Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
  Cell Stem Cell. 2016 Aug 4;19(2):192-204. doi: 10.1016/j.stem.2016.05.013
  PMID: 27345838
• Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche.
  Chen JY, Miyanishi M, Wang SK, Yamazaki S, Sinha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL.
  Nature. 2016 Feb 11;530(7589):223-7. doi: 10.1038/nature16943
  PMID: 26863982
• Identification and specification of the mouse skeletal stem cell.
  Chan CK, Seo EY, Chen JY, Lo D, McArdle A, Sinha R, Tevlin R, Seita J, Vincent-Tompkins J, Wearda T, Lu WJ, Senarath-Yapa K, Chung MT, Marecic O, Tran M, Yan KS, Upton R, Walmsley GG, Lee AS, Sahoo D, Kuo CJ, Weissman IL, Longaker MT.
  Cell. 2015 Jan 15;160(1-2):285-98. doi: 10.1016/j.cell.2014.12.002
  PMID: 25594184
• Alveolar progenitor and stem cells in lung development, renewal and cancer.
  Desai TJ, Brownfield DG, Krasnow MA.
  Nature. 2014 Mar 13;507(7491):190-4. doi: 10.1038/nature12930
  PMID: 24499815
• The bone marrow niche for haematopoietic stem cells.
  Morrison SJ, Scadden DT.
  Nature. 2014 Jan 16;505(7483):327-34. doi: 10.1038/nature12984
  PMID: 24429631
• The genome sequence of the colonial chordate, Botryllus schlosseri.
  Voskoboynik A, Neff NF, Sahoo D, Newman AM, Pushkarev D, Koh W, Passarelli B, Fan HC, Mantalas GL, Palmeri KJ, Ishizuka KJ, Gissi C, Griggio F, Ben-Shlomo R, Corey DM, Penland L, White RA 3rd, Weissman IL, Quake SR.
  Elife. 2013 Jul 2;2:e00569. doi: 10.7554/eLife.00569
  PMID: 23840927
• Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.
  Beerman I, Bock C, Garrison BS, Smith ZD, Gu H, Meissner A, Rossi DJ.
  Cell Stem Cell. 2013 Apr 4;12(4):413-25. doi: 10.1016/j.stem.2013.01.017
  PMID: 23415915

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